Rise of Nazism essays

Rise of Nazism essays After the end of the First World War, many actions were taken which indirectly lead to the rise of the Nazi party in Germany. Many of the events include the Treaty of Versailles, problems the government of Germany came across, the stab in the back theory, and the depression. This paper will talk about these events which occurred and how they correspond to the rise of the German Nazi party. One of the agreements at the Treaty of Versailles was that the industrial heartland of Germany, the Saarland, was to be worked by the Germans for the benefit of France for 15 years (lib.byu.edu/~rdh/wwi/versailles.html). With the Saarland gone it would prove more difficult for the Germans to supply iron it also made repayment of reparations less likely. The effective removal of the Saarland from German industry made the Weimar Republics position in Germany weaker. From the very start, the Weimar republic faced opposition from both sides of the political spectrum. There was potential for the reintroduction of a monarch, or even a communist state, and several attempted revolutions occurred. The public blamed their problems on the Treaty of Versailles, and in turn, blamed the government that signed it. The new government had inherited a difficult situation. It was inevitable that the new government would have faced difficulties from the start. The republic was beginning to overcome its difficulties during the mid 1920's as economic, political, and cultural improvements were occurring, and if it hadn't been for circumstances, mainly the Wall Street Crash, the republic may have prospered for many years. These circumstances gave the extremists, the Nazi's, an opportunity for advancement as the people searched for a more radical solution to the depressio...

Writing for the web - Emphasis

Writing for the web Writing for the web A website is a quick, easy and relatively cheap way to reach thousands of potential clients. Rich web content is what keeps those prospective clients coming back for more. Most people (75 per cent*) say that content quality is the most important factor governing whether they revisit a website (*Forrester Research). Yet content readability is one of the most obvious and most overlooked aspects of website accessibility. No matter how good the design of your site, and no matter how many users it gets, both are irrelevant if visitors cant or wont follow the content. Of course, websites for large organisations may have several different authors. So its easier to slip up on content readability: personal writing styles vary and can lead to confusing inconsistency. There may also be a mad dash to fill pages as soon as they are designed without enough thought given to subject matter, layout, punctuation, grammar and, most importantly, your site visitor. Good writing is not merely intuitive. Here are ten top tips on how to improve your site and ensure your content is king. 1. Start with the reader in mind. Ask yourself why theyre going to be visiting a page and what their likely thought process would be. Also, ask what things they wouldnt be interested in. 2. Use plain English. Imagine a typical customer. What terms would they use? Imagine that you are speaking to them when you write. Read the content out loud if it helps often its the process of writing that causes the problem. 3. Use the active voice, rather than the passive. So rather than saying an area is being redeveloped, say, we are redeveloping it. 4. Structure your sentences logically, by putting the what before the why. So dont write: If the company makes these changes now, it will immediately improve the service. Instead, write: The company will immediately improve the service if it makes these changes now. 5. Avoid over-long sentences. The best way to do this is to limit yourself to one idea per sentence. (This makes content much easier to write too.) 6. Use punctuation helpfully and accurately. Punctuation may seem like a small thing, but it can make a world of difference. For example, a local authority website recently left the apostrophe out of the following sentence: Residents refuse to go in the bins. The resulting meaning was probably not what the author intended. 7. Be direct. Use the word you whenever you can, and address the site visitor directly, as one person. (For example, You can find more information here.) 8. Talk. If various colleagues provide written information for your website, set up a meeting and decide on a style guide to ensure consistency. For example: use the same subheads and titles; if you use specific abbreviations make sure you all work to the same format. Discuss work in progress as a team so as not to repeat content unnecessarily. 9. Proofread. Inaccuracies can easily be missed. Be sure to print out and proofread the content, as mistakes are much harder to spot on screen. 10. Links. Links can be extremely helpful if directing the site visitor to relevant information. But be careful not to splatter your web pages with links for the sake of it. This can alienate the site visitor from the content they actually require. You dont want to send them hurtling into the www ether when they could be reading your site.

Technology in My Life Essay Example | Topics and Well Written Essays - 250 words

Technology in My Life - Essay Example Similarly, I use kitchen appliances for cooking and baking. I also make use of mobile phone to communicate with my friends and relatives. I get information about new technologies through internet research and buy the products, which I consider useful for me. For example, a couple of weeks ago, I planned to buy some new television technology to enjoy good pixel quality. I explored internet sources and came to know about light emitting diode (LED) sets, which provide excellent picture quality and enhanced view of dark scenes. Therefore, I bought a LED set, which proved to be a good choice for me to view movies and other programs. In my professional life, I make use of a range of technologies, which include laptop, iPad, fax machine, scanner, printer, and mobile phone. My company has provided all of these products to me to make me show improved productivity and efficiency. I believe that in the present age, use of technology has become critical for the success of a person in his/her professional life. Therefore, I try to make a great use of all of available technologies to show improvement in my job efficiency and

The Impact on the Ecosystem Essay Example | Topics and Well Written Essays - 1750 words

The Impact on the Ecosystem - Essay Example This cannot rule out the vast number of negative impacts that the human population has on the ecosystem around it; human beings, over the years, have become so greedy that their actions have begun to pollute rivers and lakes as well as the air that is breathed; factories have been dumping toxic wastes everywhere possible leading to hazardous manifestations like soil erosion and deforestation, not to forget further polluting the environment and making it impossible for beings to survive. Making room for more people to live on the planet has started resulting in a clash with the existing varieties of other species that fearfully roam the earth. Even though biological communities do exist, it must be noted that human beings are overpopulating the ecosystem that they live within and in the process, making life difficult for other beings that depend on water, air and soil for their well being too. Every species plays a strong role in the environment which represents a niche; this ecologic al niche encompasses the relationship that each organism has with its environment as a single entity or as a plural society. Looking at the niche from the point of view of humans, they have been impacting the environment that they live in, rather strongly and negatively at that. Within my personal local area, an ecosystem of interest would be my neighborhood – it is made up of various kinds of plants, animals and human beings, all co-existing together. The entire area has slowly been concretized over the years however it still retains its natural environment as a small lake thrives around the corner around which a number of plants and animals exist; the area is very well greened, giving the opportunity to a number of birds as well as small animals to make their home and live there. It must be understood that an ecosystem also consists of the non-living objects that are present within it for example, the air, water, soil around the living objects which assist the living object s to survive and thus live in conjunction with each other. This is why it is important to take care of not only the living but the non-living aspects of nature; water, air and soil are very integral to the survival of any human being and thus their contamination may lead to catastrophic circumstances for living beings. Most people in the area keep pets of all kinds as well – dogs, cats, birds, turtles, fish etc. Thus, this environment may be referred to as an ecosystem because all kinds of living creatures have been undergoing a basic biotic way of life in their natural environment. Nonetheless, with time, more and more buildings and housing societies have made their way into the area and this has led to cutting down of a significant number of trees. This further, has led to a number of small animals and plants living with the help of those trees (creepers, squirrels etc.) bar their home and move to a different place to seek shelter. With respect to this paper on how the ecos ystem is being impacted, it must be understood that man has interfered within nature to the extent that every individual is now taking up a lot more space in the environment than an animal or a plant would; this means that because of manmade interventions, it has become impossible for other aspects of the environment to survive within. It is every individual’s duty to understand the harmful manner in which he is contributing

The Autoimmune Hemolytic Anemia Biology Essay

The Autoimmune Hemolytic Anemia Biology Essay Autoimmunity is a disorder in which an organism loses its ability to recognize the self and non-self antigen, which would further lead to immune response against its own cells and tissues. Diseases that results from such abnormal immune responses are termed as autoimmune diseases. Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which endogenous antibodies are directed against the red blood cells and upregulated leading to erythrocyte death. This review article focuses on the types of AIHA based on the classification of the antibodies and the temperature at which they are active i.e warm AIHA, cold AIHA and mixed AIHA , based on the age of its occurance i.e adult or pediatric AIHA, causes, diagnostic techniques, diseases which may cause AIHA as a secondary disorder, treatment and its aftereffects, current and future prospectives of its studies. Abbreviations: AIHA Autoimmune hemolytic anemia, WAIHA Warm autoimmune hemolytic anemia, CAIHA Cold autoimmune hemolytic anemia, RBCs Red blood cells, DAT Direct antiglobin test. INTRODUCTION: Autoimmune hemolytic anemia (AIHA) is a disorder in which the auto-antibodies are directed against the persons own red blood cells (1). It is a relatively uncommon but not a rare disorder. It has an estimated incidence of 1 to 3 cases per 100,000 population per year (1). There are three types of AIHA based on the temperature of activity of the autoantibodies i.e warm AIHA, cold AIHA and mixed type AIHA of which warm AIHA has the most common occurance (more than 70%) followed by cold AIHA (about 20%) and mixed type has least occurance (2). Further AIHA is classified on the basis of age of the patient suffering from the disorder i.e pediatric AIHA and adult AIHA. Pediatric AIHA is from the age group of 1 to 16 (or 18) years and mostly has no underlying causes (2). Adult AIHA is from 18 years and above and is mostly associated with some underlying primary diseases. Sometimes AIHA is caused due to administration of some drugs and is called drug induced AIHA. AIHA may also be of secondary or idiopathic type. The further description of the different types of AIHA is explained below. TYPES OF AIHA: Based on the temperature at which the auto-antibodies are active: Warm autoimmune hemolytic anemia (WAIHA) It the most common type of AIHA. Warm auto-antibodies are usually IgG. It is called warm autoimmune hemolytic anemia because the antibodies have their peak activity at 370C. IgG effectively binds to the FC receptor of phagocytic cells. Hence the destruction of RBCs takes place mostly by phagocytosis. IgG may or may not fix complement. Hemolysis of RBCs also takes place in spleen. WAIHA may be idiopathic i.e when there is no primary infection causing the disorder or secondary to lymphoproliferative diseases, autoimmune diseases, viral infections, immune deficiency etc (1)(2)(3)(6). Cold autoimmune hemolytic anemia (CAIHA) Cold auto-antibodies are usually IgM antibodies. Rarely IgG or IgA antibodies can act as cold auto-antibodies. It is so called because the antibodies have their peak activity at temperature ranging from 0-40 C (1)(2)(3)(6). IgM antibodies are potent classical complement pathway activators. Hence causes complement mediated lysis of RBCs. Paraxysmal cold hemoglobinurea a form of CAIHA, is caused by cold active IgG hemolysin. It was usually associated with some underlying diseases like syphilis, measles, mumps or other viral diseases (1)(2)(6). Mixed autoimmune hemolytic anemia Both warm auto-antibodies and cold auto-antibodies are present the blood. It is more fatal than the WAIHA and CAIHA. Detection and diagnosis is also more difficult than the earlier types (1)(2)(3)(4)(6). Based on the age of the patient suffering from the disorder AIHA is classified as: Pediatric AIHA Affects the age group of 1-16 years, with a higher incidence of occurance in the first four years of life (1). It may spontaneously resolve on its own. It shows a good response to the steroid treatment. It has a severe onset and less morbity rate. Males are more prone to pediatric AIHA (2). Adult AIHA Affects the age group of 18 years and above. It is more often associated with the underlying lymphoproliferative, autoimmune and infectious diseases. Treatment is steroid therapy or spleenectomy. Has higher morbity rate compared to adult AIHA because of the difficulty or inability in treating the underlying disease (2). Based on the cause of its occurance, following are the types of AIHA: Secondary AIHA It is mainly caused due to some underlying diseases like bacterial, fungal or viral infections. The primary underlying diseases that may cause secondary AIHA are Sjogrens syndrome (10), lymphoproliferative and autoimmune diseases (2).Treatment of the secondary AIHA would also include the treatment of the underlying primary disease, for its complete remission (1). Idiopathic AIHA Has no particular underlying causes like infections or primary diseases for its occurance. Mortality rate is comparatively less than that of secondary AIHA (1). Drug induced AIHA Cause of occurance are drug molecules that binds to the surface of the RBC membrane, acts as non-self antigens, thus inducing the autoantibodies against the RBCs and further leads to hemolysis (2). Examples of the drugs that cause drug induced hemolytic anemia are Ibuprofen, Diclofenac, L-dopa, Procainamide (6). CAUSES In majority of the cases AIHA is caused due to some primary underlying diseases like lymphoproliferative, autoimmune and infectious diseases (2). For example, after the M.suis infection in pigs, warm IgG autoantibodies are directed against the RBCs and destroys it. In this case actin was the active component that played a vital role in inducing an autoimmune response. Actin acted as a target protein for the autoreactive antibody during the acute phase of the M.suis infection. The autoreactive antibody production is induced by a misguided upregulation of the naturally occurring B cells specific for self antigens, appearance of previously cryptic antigens, occurance of altered self antigens, tolerance to self antigens due to molecular mimicry. The autoimmune epitopes (in this case actin) on the RBCs may be due to contact with the proteolytic enzymes. Cytoskeleton of the RBCs gets modified by the attachment and invasion of the infectious agent. Also the infectious agent causes damage to the RBCs making the hidden cytoskeletal proteins of the RBCs accessible for the circulating antibodies. Due to all the above mentioned reasons the antibodies recognizes them as non-self and elicit an immune response (3). There are several other causes which may lead to AIHA other than due to a primary infections. For example higher incidence of occurance of AIHA after allogenic hematopoetic stem cell transplantation in adult patients. Further studies proved that the chances of development of AIHA is more in patients with HSCT from unrelated donors and also that they develop chronic extensive graft versus host disease (GVDH). In such cases it was observed that AIHA was never the primary cause of death, rather it was due to infection of GVDH (5). In some rare cases, liver transplantation or solid organ transplantation leads to the development of AIHA (11)(14)(15). DIAGNOSIS: The destruction or removal of red blood cells from the circulation before their normal life span of 120 days is called Hemolysis. Hemolysis manifests itself as acute or chronic anemia, reticulocytosis or jaundice. Intravascular hemolysis refers to the destruction of red blood cells in the blood with the release of contents into plasma. This is then followed by direct membrane degradation and cell destruction caused by mechanical trauma from a damaged endothelium, complement fixation and activation on the cell surface. On the other hand, extravascular hemolysis refers to the removal and destruction of red blood cells with membrane alterations by the macrophages of the spleen and liver. The hemolysis can be categorized broadly into the following types: HEMOLYTIC ANEMIA HEREDITARY (6) ACQUIRED (6) ( Due to infections (6) Microangiopathic (6) Autoimmune (6) Autoimmune (6) Alloimmune (6) Drug induced (2) (6) Paroxysmal (1)(2)(6) Mixed (1)(2)(3) (4)(6) Cold (1)(2) (3)(6) Warm (1)(2) (3)(6) Immune complex or Auto-antibody (6) Drug absorption (hapten induced) (6) Delayed transfusion reaction (6) Acute transfusion reaction (6) Flow chart 2: Broad classification of autoimmune hemolytic anemia. Since all the above said categories of hemolytic anemias have many similar symptoms and expressions, efficient diagnostic techniques should be developed to detect the correct category of hemolytic anemia for its appropriate treatment. DIAGNOSTIC TESTING Basic diagnosis for hemolysis on the basis of laboratory and peripheral smear findings: Hematologic tests Reticulocytosis which is the normal response of the bone marrow to the peripheral loss of blood cells is an important characteristic laboratory feature of hemolysis. Checking for the presence of reticulocytosis can be used for diagnosis of hemolysis. Review of the peripheral blood smear with an assessment for pathognomic red blood cell morphologies (spherocytes or schistocytes) along with examination of WBCs and platelets is very important for the evaluation of any anemia (6). Chemistry tests Increased unconjugated bilirubin, increased lactate dehydrogenase, and decreased haptoglobin levels are characteristic feature of the distruction of RBCs and thus can be used for diagnosis of hemolysis (6). c) In addition to the above tests, urinary tests are also be performed (6) After diagnosis of the basic hemolysis, its etiology is determined by performing further diagnostic tests. This review article focuses on the diagnostic techniques specific for AIHA. Microspherocyte on a peripheral smear and positive direct antiglobin test (DAT) is a characteristic feature of AIHA (1). The direct antiglobin test ,is also known as direct Coombs test (8). It demonstrates the presence of antibodies or complement on the surface of red blood cells which is the hallmark of autoimmune hemolysis (8). In this technique, the patients red blood cells are mixed with rabbit or mouse antibodies against human IgG or C3. The test would give a positive result if an agglutination reaction between the patients antibody or complement coated red blood cells by anti-IgG or C3 is observed. RBC agglutination with anti-IgG serum indicates warm AIHA and RBC agglutination with anti-C3 indicates the cold AIHA. However further efficient and very specific diagnostic techniques should be developed to distinguish mixed AIHA and paraxysomal cold hemoglobinuria from the other types. Also the present diagnostic techniques many a times failed to give an errorless distinction between these two types of AIHA (4). The three types of drug induced anemia based on their mechanism of their mechanism of action can be detected by a positive DAT and its type can be identified by the intravascular or extra-vascular hemolysis that it produces (6). TREATMENT: Treatment mainly depends upon the type of AIHA i.e warm antibody type, cold antibody type, mixed antibody type or paraxysomal cold hemoglobinuria and also on the secondary or the idiopathic forms. The following are the treatment options for AIHA. However each treatment stratergies has its own advantages and disadvavtages. Warm antibody autoimmune hemolytic anemia i) CORTICOSTEROIDS The initial therapeutic agent used for treatment of WAIHA patients are the corticosteroids. There is a rapid onset of response. This therapy is usually maintained for 1-3 weeks, however sudden ceasation of therapy may result in prompt relapse of hemolysis. The adverse effects of long term use of corticosteroids as a therapeutic agent would include pulmonary aspergellosis, central nervous system hemorrhage (2), osteoporosis, avascular necrosis, susceptibility to infection, abnormalities in glucose and lipid metabolism and growth suppression in children (7).The gluocorticoids may inhibit antimicrobial activity of macrophages thus showing side effects when treated with it (2). In cases of pediatric anemia, prednisolone along with folic acid supplementation was used for therapy which showed a positive response in 81% of the patients (8). ii) SPLENECTOMY Splenectomy is mainly considered in patients who donot respond to the corticosteroid therapy. The main advantage of splenectomy is that it has a potential for a complete and long term remission. The adverse effect of spelectomy would include overwhelming postspelectomy infection (OPSI) which may result in serious morbity or mortality in a small percentage of patients after spelectomy (2)(7)(8). iii) IMMUNOSUPPRESSIVE DRUGS This is the third therapeutic option after both corticosteroid therapy and spelectomy. Examples of the immuno-suppressive drugs would include azathioprine, cyclosporine (8), rituximab (9)(11) etc. iv) DANAZOLE It is an attenuated androgen with good responses and comparatively lesser side effects (2)(7). v) INTRAVENOUS IMMUNOGLOBIN In patients who doesnot respond to the corticosteroids, it is used as a second line therapy. However, intravenous immunotherapy is expensive (2)(7). vi) PLASMA EXCHANGE Used for acute reversal of severe hemolysis along with other therapeutic agents. Cold antibody autoimmune hemolytic anemia The simplest and the possible way for reducing the severity of CAIHA is avoidance of cold. Plasma exchange showed a temporary benefit in a small percentage of patients. Any other therapeutic options involved more potential risks than probable benefits. Paroxysmal cold hemoglobinuria In most of the cases hemolysis terminates spontaneously and hence only supportive care is required. Sometimes transfusion of RBCs and corticosteroid therapy may have a positive impact on the treatment. Atmost care should be taken in case of secondary autoimmune hemolytic anemia i.e the underlying diseases like chronic lymphocytic leukemia, systemic lupus erytromatous, lymphomas etc should be treated for complete remission from AIHA (7).Combinational therapy was used in some cases of AIHA as secondary infection. Example, a case in which AIHA was found in association with Plasmodium vivax infection was treated with chloroquine and primaquine (for P.vivax infection), prednisolone and transfusion of least incompatible RBCs (for AIHA) (12). CONLUSION This review article gives a very short explanation about autoimmunity as a disorder. It mainly focused on auto-immune hemolytic anemia which is a subset of autoimmunity. The types of AIHA, causes, diagnosis and possible treatment stratergies were discussed. The future area of research under this topic is in finding out more efficient and specific diagnostic techniques to detect mixed and paroxysmal cold hemoglobinuria and treatment options with maximum results and minimum side-effects. Drugs like Bortizomib (13), Alemtuzumab (humanized monoclonal antibody targeting CD52 antigen) etc are still under research for the treatment of hemolytic anemia (16).

Introduction for Dengue Virus Essay

Dengue fever, also called dengue, is a potentially serious disease caused by a virus. There are four types of dengue virus that can cause illness in humans. Dengue viruses are transmitted between humans by the bite of an infected Aedes mosquito. Dengue is rare in the U.S., but is common and a serious public health threat in warm sub-tropical and tropical areas of the world. These include areas of Central and South America, Africa, Southeast Asia, China, India, the Middle East, Australia, the Caribbean and the South and Central Pacific. Dengue fever is most common in urban areas and outbreaks occur commonly during the rainy season when mosquitoes breed heavily in standing water. The incidence of dengue fever is on the rise worldwide, and in some areas of Asia, complications of the disease are a leading cause of serious illness and death in children. Mosquitoes pick up a dengue virus when they bite a human who is already infected with the virus. The mosquito then carries it in its own blood and spreads it when it bites other humans. After a dengue virus enters the human bloodstream, it spreads throughout the body. Symptoms appear in about eight to ten days after a bite from an infected mosquito. Symptoms are flu-like and can include high fever, nausea, vomiting, body aches, and headache. Most people can recover from dengue fever, but some cases can progress into a life-threatening complication called dengue hemorrhagic fever. Symptoms of this disease include severe, uncontrolled hemorrhage and shock. For more information on symptoms, refer to symptoms of dengue fever. Making a diagnosis of dengue fever begins with taking a thorough personal and family medical history, including symptoms, and completing a physical examination. Recent travel to sub-tropical or tropical areas of the world is an important clue that may increase the suspicion of a diagnosis of dengue fever.

Settle Down The Unsettling Truth about Wedded Bliss...

Settle Down: The Unsettling Truth about Wedded Bliss â€Å"Happily ever after.† Whether in Disney movies or cheesy romance novels, these three words have been uttered a countless number of times in a manner of different ways. What society fails to acknowledge is the large impact it has on young girls and their perception of reality. This concept is not just a sweet ending to a heartwarming story that young girls can easily forget. No, rather it is a concept that is targeted at females and repeatedly encouraged by society. They are told what they should expect from relationships and marriage. Furthermore, they are told how to act and behave in order to have a functioning and healthy relationship with their significant other. However, life as we†¦show more content†¦Furthermore, societal pressures also result to girls being forces to dream in a certain way – like wanting a traditional marriage and striving to become the perfect wives to their husbands. The husban d, interestingly, is portrayed as a mannequin. The mannequin husband suggests that he is luring girls, as mannequins in stores serve the purpose of luring consumers to buy the item of clothing. Also, the mannequin suggests how numb he is to the wife and the idea of marriage because most males in society are not faced with society’s constant pressures to behave or want certain things. Society enforces this standard to mold women into believing that they want this dream – to get married, live in a nice home, and raise kids, and that it will ultimately lead them to a happier state. However, men in our society are not put to the same standard. The audience comes to know that behind this happy front and life the housewife is leading, her husband is having an extramarital affair with another woman. Worried that she might lose her husband, the wife is seen to work harder around the house. The girl tries to be the wife that she has been influenced by society to be, hoping that it will save her marriage with her partner. This is an idea society has promoted – if something goes wrong in a relationship, it is the woman’s fault. A woman should always aim to please her husband and continue being